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Malaria remains a prevalent and life-threatening disease in Nigeria, emphasizing the crucial need for effective antimalarial medications. With a plethora of options available, it can be challenging to identify the best malaria tablets for your needs. In this comprehensive guide, we explore popular antimalarial drugs, their functions, and essential information to help you make an informed choice. Remember, consulting a healthcare professional is paramount before starting any medication.

Best Malaria Tablets in Nigeria:

  1. Tafenoquine
  2. Quinine
  3. Quinidine gluconate
  4. Quinidine
  5. Quinidex
  6. Quinaglute
  7. Qualaquin
  8. Pyrimethamine-sulfadoxine
  9. Pyrimethamine/sulfadoxine
  10. Pyrimethamine
  11. Proguanil
  12. Primaquine
  13. Plaquenil
  14. Paludrine
  15. Mepron
  16. Mefloquine
  17. Malarone
  18. Krintafel
  19. Hydroxychloroquine sulfate
  20. Fansidar
  21. Daraprim
  22. Coartem
  23. Chloroquine phosphate
  24. Chloroquine
  25. Atovaquone/proguanil
  26. Atovaquone
  27. Artesunate
  28. Artemether/lumefantrine
  29. Arakoda

It’s essential to emphasize that self-medication is not recommended. Seek professional medical advice before taking any antimalarial drug to ensure the right medication for your specific condition.

Side Effects of Antimalarial Drugs:

While these drugs effectively combat malaria, they may come with potential side effects. Immediate cessation of medication and contacting a healthcare professional is advised if you experience any of the following:

  • Abdominal pain
  • Acute respiratory distress syndrome
  • Anaphylaxis
  • Anemia
  • Anorexia
  • Anxiety
  • Arrhythmias
  • Breathlessness
  • Changes in blood sugar
  • Chest pain
  • Cough
  • Diarrhea
  • Difficulty concentrating
  • Dizziness
  • Electrolyte imbalance
  • Elevated creatinine
  • Elevated liver enzymes
  • Erythema multiforme
  • Eye disorders
  • Fatigue
  • Fever and chills
  • Headache
  • Heart block
  • Insomnia
  • Jaundice
  • Kidney failure
  • Liver failure
  • Malaise
  • Muscular pain
  • Nausea and vomiting
  • Pancreatitis
  • Photosensitivity
  • Pneumonia
  • Seizures
  • Skin rash and itching
  • Stevens-Johnson syndrome
  • Suicidal ideation
  • Thrombocytopenia
  • Visual disturbances

Symptoms of Malaria:

Early detection is crucial in managing malaria. Watch out for symptoms such as:

  • Fatigue
  • Bloody stools
  • Body aches
  • Confusion
  • Convulsions
  • Diarrhea
  • Headache
  • High fever
  • Kidney failure
  • Nausea or vomiting
  • Seizure
  • Shaking chills
  • Sweating
  • Yellow skin (jaundice)

Classes of Antimalarial Drugs and Their Functions:

Understanding the broad classes of antimalarial drugs provides insights into their mechanisms:

  1. Artesunate:

    • Activated by heme iron, causing oxidative stress and inhibiting nucleic acid and protein synthesis.
  2. Chloroquine:

    • Acts against erythrocytic forms of Plasmodium; precise mechanism unknown.
  3. Hydroxychloroquine Sulfate:
    • Weak base affecting parasite’s acid vesicles, inhibiting heme polymerization, and inhibiting essential enzymes.
  4. Mefloquine:
    • Structural analog of quinine; kills schizonts in the bloodstream.
  5. Atovaquone:

    • Inhibits the cytochrome bc1 complex’s electron transport chain and collapses the mitochondrial membrane.
  6. Artemether/lumefantrine:

    • Inhibits protein and nucleic acid synthesis, affecting beta-hematin formation.
  7. Atovaquone/proguanil:

    • Collapses mitochondria, disrupts electron transport, and inhibits dihydrofolate reductase.


Choosing the right malaria tablet in Nigeria is crucial for effective treatment. This guide provides a comprehensive list of popular antimalarial drugs, their potential side effects, and essential information for symptom recognition. Remember, your health is a priority, and consulting a healthcare professional is the first step towards effective malaria management.

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